glutathione synthetase - PMC

Catherine J. Lilley, Abbas Maqbool, Duqing Wu, Hazijah B. Yusup, Laura M. Jones, Paul R. J. Birch, Mark J. Banfield, Peter E. Urwin, Sebastian Eves-van den Akker

PLoS Genet. 2018 Apr; 14(4): e1007310. Published online 2018 Apr 11. doi: 10.1371/journal.pgen.1007310

PMCID:: PMC5919673

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Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation

Haoyang Xia, Zhongzhong Liu, Wenjin Liang, Xianpeng Zeng, Yi Yang, Pu Chen, Zibiao Zhong, Qifa Ye

Oxid Med Cell Longev. 2020; 2020: 1079129. Published online 2020 Jan 21. doi: 10.1155/2020/1079129

PMCID:: PMC6996675

Article PDF–1.8M

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Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

Paul K. Fyfe, Magnus S. Alphey, William N. Hunter

Mol Biochem Parasitol. 2010 Apr; 170(2-3): 93–99. doi: 10.1016/j.molbiopara.2009.12.011

PMCID:: PMC2845819

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Select item 11120359.

A Multidomain Fusion Protein in Listeria monocytogenes Catalyzes the Two Primary Activities for Glutathione Biosynthesis

Shubha Gopal, Ilya Borovok, Amos Ofer, Michaela Yanku, Gerald Cohen, Werner Goebel, Jürgen Kreft, Yair Aharonowitz

J Bacteriol. 2005 Jun; 187(11): 3839–3847. doi: 10.1128/JB.187.11.3839-3847.2005

PMCID:: PMC1112035

Article PDF–717K

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Investigating Arsenic Susceptibility from a Genetic Perspective in Drosophila Reveals a Key Role for Glutathione Synthetase

Jorge G. Muñiz Ortiz, Robert Opoka, Daniel Kane, Iain L. Cartwright

Toxicol Sci. 2009 Feb; 107(2): 416–426. Published online 2008 Sep 8. doi: 10.1093/toxsci/kfn192

PMCID:: PMC2639754

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ASPARTATE 458 of Human Glutathione Synthetase is Important for Cooperativity and Active Site Structure

Teresa R. Brown, Michael L. Drummond, Sarah Barelier, Amanda S. Crutchfield, Adriana Dinescu, Kerri D. Slavens, Thomas R. Cundari, Mary E. Anderson

Biochem Biophys Res Commun. Author manuscript; available in PMC 2012 Aug 5.

Published in final edited form as: Biochem Biophys Res Commun. 2011 Aug 5; 411(3): 536–542. Published online 2011 Jul 12. doi: 10.1016/j.bbrc.2011.06.166

PMCID:: PMC3186441

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Emerging regulatory paradigms in glutathione metabolism

Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, Joseph J. Barycki

Adv Cancer Res. Author manuscript; available in PMC 2015 Jul 27.

Published in final edited form as: Adv Cancer Res. 2014; 122: 69–101. doi: 10.1016/B978-0-12-420117-0.00002-5

PMCID:: PMC4515967

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Molecular basis of glutathione synthetase deficiency and a rare gene permutation event.

G Polekhina, P G Board, R R Gali, J Rossjohn, M W Parker

EMBO J. 1999 Jun 15; 18(12): 3204–3213. doi: 10.1093/emboj/18.12.3204

PMCID:: PMC1171401

Summary PDF–442K

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Overexpression of glutathione reductase but not glutathione synthetase leads to increases in antioxidant capacity and resistance to photoinhibition in poplar trees.

C H Foyer, N Souriau, S Perret, M Lelandais, K J Kunert, C Pruvost, L Jouanin

Plant Physiol. 1995 Nov; 109(3): 1047–1057. doi: 10.1104/pp.109.3.1047

PMCID:: PMC161408

Summary PDF–1.9M

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Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis

Anthony Mitchell, Christina Tam, Derek Elli, Thomas Charlton, Patrick Osei-Owusu, Farbod Fazlollahi, Kym F. Faull, Olaf Schneewind

mBio. 2017 May-Jun; 8(3): e00646-17. Published online 2017 May 16. doi: 10.1128/mBio.00646-17

PMCID:: PMC5433101

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Essential Role of Glutathione in Acclimation to Environmental and Redox Perturbations in the Cyanobacterium Synechocystis sp. PCC 6803

Jeffrey C. Cameron, Himadri B. Pakrasi

Plant Physiol. 2010 Dec; 154(4): 1672–1685. Published online 2010 Oct 8. doi: 10.1104/pp.110.162990

PMCID:: PMC2996012

Article PDF–899K

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Study of Linkage between Glutathione Pathway and the Antibiotic Resistance of Escherichia coli from Patients’ Swabs

Marketa Kominkova, Petr Michalek, Kristyna Cihalova, Roman Guran, Natalia Cernei, Lukas Nejdl, Kristyna Smerkova, Simona Dostalova, Dagmar Chudobova, Zbynek Heger, Radek Vesely, Jaromir Gumulec, Jindrich Kynicky, Kledi Xhaxhiu, Ondrej Zitka, Vojtech Adam, Rene Kizek

Int J Mol Sci. 2015 Apr; 16(4): 7210–7229. Published online 2015 Mar 31. doi: 10.3390/ijms16047210

PMCID:: PMC4425013

Article PDF–2.7M

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Modification of Escherichia coli B glutathione synthetase with polyethylene glycol for clinical application to enzyme replacement therapy for glutathione deficiency.

Y Inoue, K Sugiyama, H Ueminami, S Izawa, A Kimura

Clin Diagn Lab Immunol. 1996 Nov; 3(6): 663–668. doi: 10.1128/cdli.3.6.663-668.1996

PMCID:: PMC170428

Summary PDF–240K

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Glutathione in Brain Disorders and Aging

Igor Y. Iskusnykh, Anastasia A. Zakharova, Dhruba Pathak

Molecules. 2022 Jan; 27(1): 324. Published online 2022 Jan 5. doi: 10.3390/molecules27010324

PMCID:: PMC8746815

Article PDF–720K

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Severe Hemolytic Anemia and Metabolic Acidosis at Birth with Glutathione Synthetase Deficiency and Progressive Neurological Symptoms on Follow-Up

Satoshi Ekuni, Kei Hirayama, Miwako Nagasaka, Keita Osumi, Hidehito Kondo, Erina Nakahara, Keiko Shimojima Yamamoto, Hitoshi Kanno, Yoshinori Katayama

Am J Case Rep. 2023; 24: e938396-1–e938396-6. Published online 2023 Apr 13. doi: 10.12659/AJCR.938396

PMCID:: PMC10106969

Article PDF–817K

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PMC Images search for glutathione synthetase

Fig 1

γ-Glutamyl Cycle: Glutathione is synthesized by glutathione synthetase from glutamine and cysteine in a two-step process involving the enzymes glutathione synthatase and glutamate-cysteine ligase.

19-Year Follow-up of A Patient With Severe Glutathione Synthetase Deficiency

J Hum Genet. ;61(7):669-672.
Figure 2

Levels of glutathione synthetase in Cx50D47A and Cx46fs380 lenses. (A,B) Top panels. Immunoblots of glutathione synthetase in whole lens homogenates from 1- (A) and 2.5- (B) month-old mice that were wild type for Cx50 (+/+) or heterozygous (+/D47A) or homozygous (D47A/D47A) for Cx50D47A. The migration positions of the molecular mass markers are indicated on the left. Bottom panels. Graphs show the densitometric quantification of the glutathione synthetase immunoreactive band obtained in 3 independent experiments. Data are presented as the mean (bar) + standard error of the mean. (C,D) Top panels. Immunoblots of glutathione synthetase in whole lens homogenates from 2.5- (C) and 4.5- (D) month-old mice that were wild type for Cx46 (+/+) or heterozygous (+/fs380) or homozygous (fs380/fs380) for Cx46fs380. The migration positions of the molecular mass markers are indicated on the left. Bottom panels. Graphs show the densitometric quantification of the glutathione synthetase immunoreactive band obtained in three independent experiments. Data are presented as the mean (bar) + standard error of the mean. Asterisk denote a significant difference compared with wild-type lenses (p < 0.05). Levels of glutathione synthetase in 2.5-month-old heterozygous Cx50D47A lenses were not significantly different than wild-type (p = 0.07).

Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens?

Biomolecules. 2020 Oct;10(10):1418.
FIG 1

Trypanothione biosynthetic pathway in T. brucei. GS, glutathione synthetase; γ-GCS, γ-glutamylcysteine synthetase; TryS, trypanothione synthetase; TR, trypanothione reductase; ODC, ornithine decarboxylase; AdoMetDC, S-adenosylmethionine decarboxylase.

Genetic Validation of Trypanosoma brucei Glutathione Synthetase as an Essential Enzyme

Eukaryot Cell. 2014 May;13(5):614-624.
Figure 1

A-loop of human glutathione synthetase. (1a) Model of A-loop in reactant form with glycine and ATP. (1b) ClustalW sequence alignment of A-loop of hGS. The dark box indicates charge conserved Asp458.

ASPARTATE 458 of Human Glutathione Synthetase is Important for Cooperativity and Active Site Structure

Biochem Biophys Res Commun. ;411(3):536-542.